Syncope

Introduction

  • Syncope is defined as loss of consciousness due to cerebral hypoperfusion, characterized by a rapid onset, short duration, and spontaneous complete recovery.
  • A good history and physical examination are critical in identifying causes of syncope.
  • Evaluation of the patient should answer:
    1. Is there a serious underlying cause that can be identified?
    2. What is the risk of a serious outcome?
    3. Should the patient be admitted to hospital evaluation?

Definitions and Differential Diagnosis

  • Transient Loss of Conciousness (TLOC) is a broad category split into nontraumatic and traumatic causes
  • Syncope is defined as a TLOC due to cerebral hypoperfusion, characterized by rapid onset, short duration, and spontaneous complete recovery
  • Presyncope is defined as the signs and symptoms (prodrome) before syncope, with or without a subsequent LOC
  • Seizures, pseduo-coma, intracranial hemmorrhage, TIA, metabolic disorders, intoxication and cataplexy can be falsely diagnosed as syncope. Click here for full list.
ESC Transient Loss of Consciousnes Differential

Pathophysiology and Classification of Syncope (ESC)

  • Causes of syncope all lead to the same result: fall in systemic BP and resulting cerebral hypoperfusion (defining feature of syncope)
  • Mean Arterial Pressure = Cardiac Output x Systemic Vascular Resistance. Thus each of the following causes a decrease in cardiac output and/or peripheral resistance.

1. Reflex (neurally mediated) syncope

  1. Vasovagal:
    1. Orthostatic VVS: standing, less common sitting
    2. Emotional: fear, pain (somatic or visceral), instrumentation, blood phobia
  2. Situational:
    1. Micturition
    2. Gastrointestinal stimulation (swallow, defaecation)
    3. Cough, sneeze – post-exercise
    4. Others (e.g. laughing, brass instrument playing)
  3. Carotid sinus syndrome
  4. Non-classical forms (without prodromes and/or without apparent triggers and/or atypical presentation)

2. Orthostatic Hypotension

  1. Drug Induced: vasodilators, diuretic
  2. Volume depletion: dehydration, hemorrhage, vomiting, etc.
  3. Primary autonomic failure: Parkinson’s disease, multiple system atrophy, Lewy body dementia
  4. Secondary autonomic failure: Diabetes, amyloidosis, spinal cord injuries, renal failure

3. Cardiac:

  1. Bradycardia: sinus node dysfunction (including bradycardia/tachycardia syndrome) – atrioventricular conduction system disease (ie. complete heart block).
  2. Tachycardia:
    1. Supraventricular
    2. Ventricular
  3. Structural cardiac: aortic stenosis, acute myocardial infarction/ischaemia, hypertrophic cardiomyopathy, cardiac masses (atrial myxoma, tumours, etc.), pericardial disease/tamponade, congenital anomalies of coronary arteries, prosthetic valve dysfunction
  4. Cardiopulmonary and great vessels: pulmonary embolus, acute aortic dissection, pulmonary hypertension

Note: LOC has four specific characteristics: short duration, abnormal motor control, loss of responsiveness, and amnesia for the period of LOC

Diagnostic Approach

Initial Evaluation

  • Determine if true loss of consciousness/syncope and rule out other causes: seizure, psychogenic, etc
  • Gather history from witnesses (where possible)
  • Physical exam, including supine and standing blood pressure (see orthostatic challenge below)
  • ECG
  • Blood tests (hemoglobin, electrolytes, etc.)
ESC Initial evaluation and risk stratification of patients with syncope

History

  • It is crucial to take a detailed history from the patient, and any witnesses to help come to a diagnosis. Below are listed low and high-risk features of syncope.
  • Questions to consider asking: 
    • What’s the last thing you remember?
    • Did you have a chance to brace yourself?
    • Did you know something was about to happen?

Low Risk:

  • Associated with prodrome (light-headedness, warmth, nausea, vomiting)
  • After sudden unexpected sensation (sound, smell, pain)
  • Associated with prolonged standing
  • During a meal or post prandial
  • Triggered by cough, defecation, or micturition
  • Occurring with head rotation
  • Standing from supine/sitting position
  • Recurrent history

High Risk:

  • New onset of chest pain/discomfort, dyspnea, headache
  • Syncope when supine or during exertion
  • Sudden onset of palpitation preceding syncope
  • No warning or prodrome
  • Family history of sudden cardiac death at young age
  • Syncope in sitting position
  • Severe structural or coronary disease

Physical Exam

  • General exam, to rule out consequences of trauma and a cardiac exam is needed to help determine whether structural causes are present.

Low Risk:

  • Normal Examination

 

High Risk:

  • Unexplained systolic BP <90mmHg
  • Persistent Bradycardia <40bpm when awake and absence of physical training
  • Undiagnosed systolic murmur

ECG

  • Bifascicular block (defined as either left or right BBB combined with left anterior or left posterior fascicular block)
  • Other intraventricular conduction abnormalities (QRS duration >0.12 s)
  • Mobitz I second-degree AV block and 1-degree AV block with markedly prolonged PR interval
  • Mobitz II second degree and third-degree heart block
  • Asymptomatic mild inappropriate sinus bradycardia (40–50 b.p.m.) or slow atrial fibrillation (40–50 b.p.m.) in the absence of negatively chronotropic medications
  • Non-sustained VT
  • Paroxysmal A.Fib or SVT
  • Pre-excited QRS complexes
  • Long or short QT intervals
  • Early repolarization
  • ST-segment elevation with type 1 morphology in leads V1-V3 (Brugada pattern)
  • Negative T waves in right precordial leads, epsilon waves suggestive of ARVC
  • Left ventricular hypertrophy suggesting hypertrophic cardiomyopathy

Special Tests

Orthostatic Challenge

  • Should be performed in anyone presenting with syncope.
  • Diagnostic criteria: Abnormal BP fall is defined as a progressive and sustained fall in systolic BP from baseline value >20 mmHg or diastolic BP >10 mmHg, or a decrease in systolic BP to < 90 mmg Hg.
ESC 2018 - Association of orthostatic intolerance and orthostatic hypotension

Carotid Sinus Massage

  • Can be performed in individuals above the age of 40 (carotid sinus hypersensitivity is quite common in younger individuals).Cardioinhibitory CSH was defined as asystole of 3 seconds or more with a drop in SBP of less than 50 mm Hg (vasodepression). Specificity increases with age and if syncope recurs with carotid sinus massage. 
  • Carotid sinus syndrome is diagnosed if the above test reproduces syncope/pre-syncope. This is usually in patients with syncope suspected to be due to a reflex mechanism. 
  • How to perform the test: Click here
Practical Instructions for the 2018 ESC Guidelines for the diagnosis and management of syncope

Cardiac Evaluations

Electrocardiographic Monitoring

  • ECG monitoring is indicated if there is high suspicion for an arrhythmogenic cause (see ECG section above).
  • Correlation between symptoms and ECG recording is the gold standard for diagnosis cardiac syncope.
  • Immediate in-hospital monitoring is indicated (ie. telemetry) in high risk patients.
  • Low risk patients managed as an outpatient, the decision depends on frequency of events to determine length of monitoring needed (ie. several days with a holter vs several months with an implantable loop recorder).

Echocardiography

  • Indicated in patients when there is previous known heart disease, data suggestive of structural heart disease, or syncope secondary to cardiovascular cause

Exercise Stress Testing

  • Indicated in patients with syncope during or shortly after exertion

Diagnosis

Reflex and Orthostatic

  • Vasovagal syncope is highly probable if syncope is precipitated by pain, fear, or standing, and is associated with typical progressive prodrome (pallor, sweating, and/or nausea).
  • Situational reflex syncope is highly probable if syncope occurs during or immediately after specific triggers (see above).
  • Syncope due to OH is confirmed when syncope occurs while standing and there is concomitant significant OH.
  • In the absence of the above criteria, reflex syncope and OH should be considered likely when the features that suggest reflex
    syncope or OH are present and the features that suggest cardiac syncope are absent (see above list).

Cardiac

  • Arrhythmic syncope is highly probable when the ECG shows
    • Persistent sinus bradycardia <40 b.p.m. or sinus pauses >3s in awake state and in absence of physical training;
    • Mobitz II second- and third-degree AV block;
    • Alternating left and right BBB;
    • VT or rapid paroxysmal SVT;
    • Non-sustained episodes of polymorphic VT and long or short QT interval;
    • Pacemaker or ICD malfunction with cardiac pauses.
  • Cardiac ischaemia-related syncope is confirmed when syncope presents with evidence of acute myocardial ischaemia with or
    without myocardial infarction.
  • Syncope due to structural cardiopulmonary disorders is highly probable when syncope presents in patients with prolapsing
    atrial myxoma, left atrial ball thrombus, severe aortic stenosis, pulmonary embolus, or acute aortic dissection.

Management

Risk Stratification

  • Consider using validated risk score to triage patients though none shown to be better than clinical judgement
  • ESC proposed triage for admission vs discharge:

General Approach

  • Further management should be direct based on above evaluation to confirm diagnosis
  • Once diagnosis confirmed, management should be instituted accordingly (ie. complete heart block –> recommend pacemaker)
2018 ESC Guidelines for the diagnosis and management of syncope
The general framework of treatment is based on risk stratification and the identification of specific mechanisms when possible

Reflex Syncope

  1. Education and lifestyle modifications is mainstay of treatment (Class I):
    1. Reassurance
    2. Recognition of prodromal symptoms in order to sit or lie down and activate counterpressure manoeuvres without delay. 
    3. Avoid triggers: Cough suppression in cough induced syncope, micturition in the sitting position, avoiding crowded places, etc. 
    4. Increased intake of oral fluids is also advised. 
    5. Salt supplementation at a dose of 120 mmol/day of sodium chloride
  2. Discontinuation/reduction of hypotensive therapy
  3. Physical counterpressure manoeuvres (effective in younger individuals [<60 years of age] with prolonged prodrome)
  4. Pharmacologic Therapy:
    1. Fludrocortisone may be considered in young patients with the orthostatic form of VVS, low–normal values of arterial BP, and the absence of contraindication to the drug.
    2. Midodrine may be considered in patients with the orthostatic form of VVS

Note: VVS = Vasovagal Syncope

Orthostatic Syncope

  1. Education and lifestyle measures,as above in reflex syncope (Class I)
  2. Adequate hydration and salt intake (Class I) – note distinction between Reflex syncope and Orthostatic Syncope here
    1. Targeting 2–3 L of fluids per day
    2. 10 g of sodium chloride
    3. Rapid ingestion of cool water can be effective in combating orthostatic intolerance and postprandial hypotension.
  3. Discontinuation/reduction of vasoactive drugs (Class IIa)
  4. Counterpressure manoeuvres (Class IIa)
  5. Abdominal binders and/or support stockings (Class IIa)
  6. Head-up tilt sleeping (Class IIa)
  7. Pharmacological (Class IIa):
    1. Midodrine: Dosage (2.5–10 mg t.i.d) was shown to be effective in some RCTs
    2. Fludrocortisone (Observational Data) in conjunction with head-up tilt sleeping

Cardiac Syncope

  • Management depends on pathology, for example pacemaker/ICD for arrhythmia and surgical consideration for aortic stenosis
  • For more information on management of cardiac syncope and indications for cardiac implantable device, see topic Cardiac Syncope Management, Aortic Stenosis, Hypertrophic Cardiomyopathy

Further Reading

  • 2018 ESC Guidelines for the diagnosis and management of syncope (html) (pdf)
  • ACC/AHA/HRS Versus ESC Guidelines for the Diagnosis and Management of Syncope: JACC Guideline Comparison. (html)

Authors

  • Primary Author: Dr. Dimitar Saveski (MD, FRCPC, Internal Medicine Resident)
  • Author/Reviewer: Atul Jaidka (MD, FRCPC, Cardiology Fellow)
  • Staff Reviewer: pending (MD, FRCPC[Cardiology])
  • Last Updated: April 7, 2020
  • Comments or questions please email feedback@cardioguide.ca
Print Friendly, PDF & Email